Hi,
Unfortunately, the 653x boards can only be configured on a line-by-line basis for asynchronous digital I/O.
When in synchronous pattern acquisition/generation mode, the 653x is divided into 2 groups (2 ports in each group). These two groups can be operated independently as input or output and at different clock frequencies. However, all lines on both ports of a group are configured in the same way.
If you are looking for completely individually controlled lines in a pattern generation/acquisition application, you might consider the new high-speed digital board (NI 655x).
Hope that helps. Have a good day.
Ron