Jeff,
I would recommend that you start by looking at the Serial Compatibility VIs in the online help. The basic LabVIEW program, will use a Serial Port Init to configure the serial port (should only need to be done once), serial port write to transmit data (will usually be done many times in the program), a bytes at serial port wired to the read serial port to read the data that the instrument you transmitted sent, and finally a serial port close (done at the end of the program). Additionally, you can look at the serial communication examples.
You will need to know the valid commands for the Fluke 45 in order to communicate it. Likewise, you will need to know what the responses look like in order to decode the response.
Regards,
Aaron
LabVIEW Champion, CLA, CPI