If there is a reason to configure the serial port, then do it first. If you are just controlling the handshake pins, I don't think you would need to configure it for data transmission but it wouldn't hurt. If you want to try to just use the property node, all you would need is a VISA Resource Name defined. You can simply right click on the reference input and select Create>Control or Create>Constant. Once you have a resource name, you can enter tha name of the port or click on the arrow to get a list of resources on your pc. If you are developing on a pc that doesn't have the port you will be eventually using, right click on the resource name and select Allow Undefined Names so you can enter any name you want.