DJD,
I assume you are running Windows 2000 (possibly XP). The reboot is likely caused because the application is causing a BSOD (Blue Screen of Death). The default settings in Windows 2000 generate a reboot with a BSOD. You should change this in System Properties (Winkey-Break, or right-click on My Computer and select properties). Change to the Advanced tab and select "Startup and Recovery". Uncheck the box to automatically reboot.
When you determine what the BSOD is, repost it and someone may help identify the cause. You may also want to upgrade to NI-488.2 2.0, which is available through this website.