Hello Andreas!
I don't know the Keithley 6487 but If you look at the Keithley websites there you can read that the Instrument Driver "Requires Installation of Keithley I/O Layer (KIOL-850)".
http://www.keithley.de/products/locurrhiresist/?path=6487/Downloads
Did you installed this I/O Layer?
The Keithley I/O layer software manages the communications between Keithley instrument drivers and software applications and the instrument itself. The I/O layer handles differences in communications required to support GPIB, serial, Ethernet, and other communications busses so that drivers and software applications do not need to handle the differences themselves.
More Information you get here:
http://www.keithley.de/com/data?asset=50493
Keithley I/O layer download:
http://www.keithley.de/com/data?asset=50494
Regards,
WolfgangZ