Hi Nishant:
I think I don't understand you very well. If you are using OpenFile, CloseFile and WriteToSpreadsheet VIs, you are not dealing with excel files, but text files.
Writing to file is costly in time. You can:
Open the file just once and
during de process use just file writing VIs as 'write to spreadsheet'... or a more simple one 'write file'
Close the file once at the end.
If you need the process to be faster, you can save all the data at 10ms rate in an array and write to file at the end.
Or write to file every second what you got the last second.
Hope it helps
Aitortxo.
Aitortxo.