Thanks for your feedback Ed - definitely some points to bear in mind there.
Yep, I'm sure it would take a few days to get used to a new input device like a tablet - but I'm thinking it could well be worth it in the long run, mainly because of the considerably increased comfort/reduced RSI risk (it's so much more natural holding a pen than a mouse).
Wacom's tablets are highly configurable (reading their manuals), different settings and configuations can be associated with different applications. On their high end "Intuous" range they also have an extra area of click switches that can be configured for shift, ctrl, alt, mouse clicks, keyboard shortcuts, etc, and also touch sensitive scrolling strips (used with your spare hand).
A few things hold me back - slight uncertainty as to whether it would be effective (given the high price), and the required desk top space (even the small active area models are fairly large overall).
Mark.