These are serial port errors. In case you didn't know, an easy way to get an error explanation is to right click on the code number of the error cluster and select Explain Error. Unfortunately, there's a lot that can go wrong with serial communication. Check baud rate, parity, stop bits, cable wiring, termination characters, etc. Are you using VISA or the old serial VIs? One thing I do when forced to use serial comm is to first verify a good connection with something like Hyperterminal. Hope this helps.