Did you actually replace the old serial functions that come with 7.1 with the functions from 6.1? The old serial driver serpdrv was dropped in LabVIEW 7 and the compatability functions of the same name actually use VISA. Open the serial functions in your VI and see if they're calling VISA at the lower levels. If that's the case, you need to install VISA. When you build an app, you can choose to include serial support when you create the installer. Click the Advanced button on the Installer tab.