Normally, serial data is only present on the Receive Data line of the serial port (that's why it's serial communication and not parallel). There are other input lines of a serial port that are normally used for handshaking. They are Data Carrier Detect (1), Data Set Ready (6), Clear To Send (8), and Ring Indicator (9). You can wire your three different signals from the device to a single RS-232 cable and use any three pins that you want. Instead of using the serial read, you would use a VISA property function and choose Modem Line Settings. Then pick the specific line that you've wired the signals to.