There's not much for me to try. I know that ASRL1::INSTR is com1 on my pc and I use that all of the time. What exactly are your trying to do? I see a 'string to write' control. What are you connected to? It looks like a command string for an instrument. What make and model. Most serial instruments require a termination character. Are you appending this on the block diagram? If you are not, then check your user manual for the correct termination. It's often a CR, LF, or both. You can also set your string control to do this just like the shipping example called Basic Serial Write and Read. In that, the string control is set for '\' Code Display and a \n character (LF) is used. You've also got these constants on the string palette.