Hi Eliran,
The USB 8451 supports only 8 bit communication.
This KB has a suggestion on how to implement 16 bit commands. "The approach you would take when writing or reading a 16 bit number is
to write or read a byte array of length 2. You can use a Type Cast to
convert back and forth between arrays of 8 bit integers and arrays of
16 bit integers."
Hope this helps!
Warm regards,
Karunya R
National Instruments
Applications Engineer