Are you wanting to know the differences in programming RS-232 and gpib instruments? If that's the case, then the answer is, there doesn't ahve to be any difference at all. If an instrument driver is designed correctly with VISA functions, then that single driver will work for gpib, serial, vxi, pxi, etc. instruments. There used to be a separate set of functions for serial communication by NI has dropped them from LV7 and only supports VISA now. You may find some older instrument drivers that use the gpib function calls but it's very easy to convert to VISA if you need to use them.