Seems like I placed a small (maybe 30ms) delay at the end of the serialcommunications.vi structure.. for some reason my PC didn't like running as fast as it tried to go. Also look into the actual serial communication.vi and open the vi's inside it - check that the port setting (0 or 1) are ok, the baud rate (probably 9600) are ok. I'm running with only three wires in my application, TX, RX and Common. The PC may need to be rebooted to enable the com port - or use device manager and see if it says the com ports 0 and 1 are both OK..
Try buildinga loopback plug with TX to RX, RX to TX, and Common to Common and see if hyperterminal (or other serial communications program works - there is also Loopback.VI in the NI library somewhere that can be used. Good Luck!! Dave