Always did and will do, never had any problem. Did this also for Adobe that we had a strange error during a failed update and the solution was delete everything after the uninstallation. Folders and key registry.
You need to check what you're deleting obviously. One of our internal solution I found during a failed LabView 2022 installation ("Unable to load MIFSystemUtility DLL") is to just delete 2 registry keys then install again, and works like a charm ("HKEY_LOCAL_MACHINE\SOFTWARE\National Instruments\Common\Installer\MIF" and "HKEY_LOCAL_MACHINE\SOFTWARE\WOW6432Node\National Instruments\Common\Installer\MIF")
I use the windows registry since 1995 when I had my first Windows, never had a problem.
If you want to reinstall from scratch as if you didn't ever installed anything, you need to do this. If you're unsure on what you're doing, use a "install sniffer" that trace every modification (file and folders created, new registry keys) done on the PC. Discard the ones that don't relate to the software you're installing and voila'.
If you still not sure or you had problem like you said, just don't do it. It's better avoid to do something you're not sure to.
Or use a Virtual Machine to do some tests before doing it (I'm doing that too, don't think I'll go directly with experiments to user PC, I try first on mine and on VM if I'm doing it the first time).
In fact I'll use one VM now to test the installation of both 2022 and 2025 to check if maybe the procedure we're using have some flaw (I don't think so, we just select 4 plugin and that's it, but anything could be), the complete uninstall (with folders and reg key deletion of course) and reinstall.
