louX2,
I have a few questions in response. First, how is the data organized in the Excel spreadsheet? If it is a few individual cells, then I would suggest looking at the Excel shipping examples that come with LabVIEW that show how to read and write to a few cells using ActiveX. Second, what version of LabVIEW and Excel will you be using? Each version of Excel has a slightly different ActiveX interface which means it is very hard to run the same VI on two different systems that have differing version of Excel. This is solely a Microsoft issue.
Let me know if these suggestions do not point you in the right direction.
Randy Hoskin
Applications Engineer
National Instruments
http://www.ni.com/ask