Hi Rob,
This sounds like an issue with the FTDI virtual com port drivers really. Does the device respond to any communications using other methods (eg: Hyperterminal) once it's fatal error-ed in CVI?
What precisely is the error message you receive when the lock up occurs? Is it an error message generated from CVI or from Windows?
Have you checked with FTDI whether there are any updated virtual com port drivers?
Cheers,
Mark
National Instruments
Applications Engineer