The 1424 should be able to acquire from a pixel clock of up to 50 MHz. It sounds to me like the pixel clock is either above 50 MHz, the pixel clock has a duty cycle that fluctuates, there is noise in the system that causes the higher frequency clock to get distorted, or that the 1424 isn't performing up to spec.
If you have another 1424, then the last part is easiest to test. Otherwise, scoping the digital lines may be a good place to check. If the differential signal is messy, then it is possible that the 1424 would miss a 45 MHz signal, but catch the 22.5 MHz signal.
Please keep me abreast on your progress!
Kyle V