Hey Kevin,
Take a look at the "Mask Example.VI" found in the NI Example Finder. And also take a look at the Histogram Example.VI and see how you can use the ROItoMask VI, and then incorporate it into the Mask Example and this should help do what you are trying to do. It sounds as if you might be leaving out the IMAQ Mask VI, which is why the ROItoMask is only giving you just white inside of the ROI in your resulting image.
If, after trying this out, and you are still having some difficulties, you can attach your code and we can take a look at it. Hopefully these examples will get you on the right path. Please keep us updated on how things are going. Thanks and have a great day.
Regards,
DJ
Applications Engineer
National Instruments