Greetings,
You should be able to use any AT-MIO-16E-2 with version 5.1 of NI-DAQ. When you install the new AT-MIO-16E-2, is it present in the NI-DAQ Configuration Utility? If so, are you able to Test Resources and Run Test Panel (available after you press the Configure button)? Also, does the new AT-MIO-16E-2 appear in the Windows Device Manager? If so, does it indicate any problems/conflicts?
Good luck.
Spencer S.