If, for instance, you have a MainSequence/Main Label step named "Label", you can make a statement in another part of Main to change the description with RunState.Sequence.Main["Label"].Description = "12345" (Note that this is a TestStand step; I'm guessing there is a simple analogous VB command). This will change the value during run time, but it will revert back by the time the sequence is complete.
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