Hi ttb,
As Ray pointed out it is possible, but you may want to consider using FrontEndCallback sequences to perform TestStand engine/variable manipulation with. This is exactly how the login/logout process is done. FrontEndCallbacks give OIs an easy way to execute a sequence that is more related to UI/application operations than test operations and accessing TestStand engine/variables is quite a bit easier from within them than your OIs source as well. Look at the TestStand User Manual for more information on FrontEndCallbacks.
Jason F.
Applications Engineer
National Instruments
www.ni.com/ask