Even though a gain of 100 is applied to a signal, the driver actually automatically adjusts the value back to the original range after the analog to digital conversion. The gain is applied prior to the A to D conversion in order to take advantage of the full range of the A to D converter in order to maximize resolution. As for the null offset, I would recommend taking a look at the LabVIEW example below that illustrates how to accomplish this. Respond if you still have problems.
Example