I just discovered something. The second initialize function is not really an initialize function. It uses the same icon but it is really KE24xx Initiate and thats much different. So, it would seem that the problem is with the measure function. Right click on it and select SubVI Setup. On the dialog box, check the bottom three boxes. Now, the Measure VI will pop-up and be paused. You can experiment with changing the front panels controls (i.e. elements) and run it over and over again without re-running the whole thing. Before you run it the first time, check that the instrument is showing the correct values. If you still can't get it to work, you really need to contact Keithley. All of the actual instrument commands are hidden in the DLL that they wrote and without the source code, it's impossible to determine what's wrong.