You need to connect the two computers' serial ports with a Null Modem Cable (Tx/Rx, CTS/RTS, DTR/DCD reversed). The put the attached vi on computer A. It will send a command from an array, and wait for a response from computer B. If the response is Yes, then the next command will be sent. If not Yes then A will send the same command again and wait for a response. There is an Abort button if you want to abort, but it will only abort the current command. You can modify it to abort the whole thing by using a while loop to replace the for loop, and using the abort button to exit the while loop. I'll leave the coding up to you. You will have to write a vi to reside on B. I'll describe it but you can code it, good practice. Computer B should start off initializing the com port, like in the attached vi. Then loop at Bytes at Port until some bytes come in, then read the bytes. Use a comparison (equal) to check if the data is good. Use a case structure to define what to send back to computer A (Yes or No). Then write it back using Visa Write. Loop around the entire thing except for the com port init. Close the Visa after the main loop.