Yes, you should be able to communicate to your instrument through your serial port. Commands sent to an instrument consist of character strings that the instrument should interpret and perform the desired action. This is true across the GPIB bus and serial ports. You will have to determine what commands are required by your instrument, and send those from your application. For instance in LabVIEw you could use VISA, Serial, 488.2 or 488 vi's to write and read from the correct interface. If you are interested in using a driver that is already developed, we do have a driver for GPIB listed on our web site:
ni.com>>downloads>>instrumetn drivers...
This would require purchasinga GPIB board, but it may be worth it compared to the time to develop a driver for serial.
Also,
if you are looking to deveolp a driver, we do have information for this on our web site:
ni.com>>resource library>>instrumetn drivers...
Good Luck with your application!
Best Regards,
Chris D
Applications Engineer
National Instruments