Under the hood VISA is using the POSIX serial interface for Mac OS X (same as for Linux and Solaris). This interface does not support changing the buffer size. Hence, the buffer size is fixed to the internal OS buffer size. The only thing that changing the buffer size will do (for the out buffer) is to have VISA not flush the data after every write. This is a limitation in the serial API for Mac OS X. Therefore, VISA reports a warning.