I'm confused as to what you mean when you say you are entering the bios with Hyperterminal. Do you really mean you are changing the serial port parameters such as baud rate, partity, etc. and are communicating to an instrument or other pc over the serial port? What exactly are you connecting to? When connected to another device over the serial port, one thing that Hyperterminal does is send a termination character at the end of each string that you type. By default, I think this is a Carriage Return. In LabVIEW, you have to add this to your program. Two shipping examples, Basic Serial Write and Read and Advanced Serial Write and Read show two different methods for this. The first has '\' Code Display enabled for the string control where the command is given. The '\' Code for Carriage Return is \r. The code for line feed is \n. The second example uses a VISA property node to set the termination character for VISA Writes.