Are us using any single VIs with a lot of stored data (e.g. in front panel graphs)? This can be done with Express VIs fairly silently, since some of them cache previous data. Is there a specific VI causing an issue? If so, turn off everything else (browser, email, etc) to free up as much memory as you can before trying to load it. Then change all array sizes to about 10 and run it. This should clear the buffers. Save it and you should be good.
Note that single arrays in LV require contiguous data space, so you can have lots of small memory pieces - lots of free memory - and still get out of memory messages if there is not a large enough open memory section available.
