This is exactly what machine vision systems are designed to do.
Might take a look at NI's smart camera line, I built a system a few years back that would look at an LCD and see if all the pixels were toggling.
Take a reference picture, then locate the points of interest and tell the camera to compare the two. Can do any number of things including toggling external relays, sending commands to other instruments, or simply turning on a red light... all right within the camera itself.
