Hi Mark,
NI-VISA is a driver layer that is used to communicate to Serial, GPIB, VXI and PXI platform.
In reality the drivers that you use with Lookot do not make use of this driver layer called VISA (which is used for the most part in the instrument control area).
Normally the terminology (Instrument Driver) is not used in Lookout (or in any SCADA system). So the answer for your question is no, you cannot use NI-VISA with Lookout, with Lookout you either use the drivers object that comes with the package or you use an OPC server (normaly provided by the hardware manufacturer, this hardware is normally a PLC) to provide data to Lookout.
I hope it helps
Regards
Andre Oliveira
Applications Engineer
National Instruments