JW_Tech,
This is strange. I would have them verify that they don't have serial port conflicts in Windows. For example, if they open a Hyperterminal session for COM1, I wonder if that will also affect COM2. There is one last thing to verify. In Lookout, go to the Options menu and select System... . In there, on the right-side of the screen, make sure that the "Log alarms to:" window is set to none.
Unless we are missing to find an object that tries to open the serial port, I cannot see why it is trying to open COM2.
I hope that helps,
GValdes