Nick-
Check all your external connections and make sure they match up correctly (encoder phases, axes numbers, limit switches, etc). You'll also want to take a look at MAX and check that all the settings are right for your motor and encoders. Then go into 1D-interactive and try moving just one axis, without encoders. If this works, then the encoders may be connected incorrectly. Check the manual for the motors and the drive to confirm that.
These troubleshooting steps should get your system up and running.
Julie S.