Hello lichti,
You may see your source float of the maximum working range (saturation) when in differential mode.
Please see the 621X Manual for actions to take:
Pages 5-2, 5-5, 5-6, 5-7
http://digital.ni.com/manuals.nsf/websearch/796D7F547CCC871186257248007A61DB
Peter Griese
NI