Bob,
Here is what you need to do to be able to call 2 end channels and create a route though 3 layers.
1) You have to tell NISE how the independent relays are connected to each other. You will do that by creating Hardwires.
2) You need to tell NISE that you want the channels connected to the hardwires to be used for routing. You will do that by marking the connected channels as "Reserved for Routing".
3) You can name the end channels according to your topology. COM for the single input channel and CH0 to CH15 for the output channels by creating aliases.
In the route editor, you will only need to create a route between COM and CHx and NISE will find the appropriate relays to close. In the route editor, if you only want to see the channels with an alias (COM, CH0, CH1 etc...) select in Options "Hide channels without aliases"