The NI 4050 and NI 4060 DMMs are both programmed with the NI-DMM instrument driver. In this driver are functions for acquiring data in a multi-point fashion.
The DMMs, however, do not make a distinction between 1-wire and 2-wire measurements. All measurements made by the DMM are differential, 2-wire measurements. Even 4-wire resistance measurements are in reality 2-wire voltage measurements, with 2 extra leads carrying the excitation current to the resistor in question.
1-wire and 2-wire configurations usually refer to the mode the switching front end is using to route signals to the DMM. The front end switch always has a 2-wire output. The difference between a 1-wire and 2-wire mode in this case is whether the negative channel of the switch output is a connected to
a common reference (1-wire, single ended), or if it is connected to a individual reference (2-wire, differential).
So, you configure the switch front end for a 1-wire or 2-wire mode, but the DMM is always looking at the same two terminals. The only difference is what actually gets connected to the negative terminal of the switch output (DMM input) - either a common reference or differential reference.
