Why is the PXI-2575 not recommended for 2-wire resistance measurements?

[Nicole13]

The spec for the NI PXI/PXIe-2575 says "Note   The NI PXI/PXIe-25-75 is not recommended for 2-wire resistance measurements". Why is this? If I want to perform 2-wire resistance measurements, what would be a good alternative?

[crossrulz]

It really depends on your measurement.  The problem with 2-wire resistance measurements is that the resistance of the wiring and the switch path will be included in your measurement.  If you are measuring in the kOhms to MOhms, this should be neglible.  But measuring anything smaller will add a large error.  That is why 4-wire resistance measurements are recommended.  The sense lines can measure the voltage across the part you actually want to measure and an accurate measurement can be made.

This is true for all switches.

My philosophy is to use 4-wire measurements except when checking for an open.